[ Mahidol University. Journal of Pharmaceutical Sciences - ONLINE ]
[ By Faculty of Pharmacy, Mahidol University. THAILAND]
Mahidol University Journal of Pharmaceutical Sciences
Abstracted/Indexed in SciFinder since 1974 (former name  "Warasan Phesatchasat")
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The Mahidol University Journal of Pharmaceutical Sciences is committed to the timely publication of innovative papers and reviews. Manuscripts submitted for publication in this journal must not have been previously published and are not under consideration for publication in any other media. All manuscripts accepted for publication are peer-reviewed... read more


A Thai Herbal Recipe Induces Apoptosis in T47D Human Breast Cancer Cell Line

T. Kummalue*, Y. U-pratya, U. Lueangamornnara and W. Jiratchariyakul

One of the most common Thai herbal recipe used by cancer patients was investigated for antiproliferative activity on human breast and lung cancer cell lines: T47D and A549, respectively. This herbal recipe was composed of five medicinal plants, i.e., Gelonium multiflorum, Rhinacanthus nasutus, Acanthus ebracteatus, Smilax corbularia, and Smilax glabra, in the equal proportion. The herbal recipe was boiled in 3 liters of distilled water until water was approximately 1 liter left. Then, the evaporating and drying processes were performed by using desicccators to yield the herbal extract. The ED50 values of T47D and A549 were evaluated using MTT method at 48 hours. The antiproliferative effect on T47D was demonstrated with ED50 value at 6,066 μg/ml, whereas no ED50 value was found with A549. The apoptotic study was done and found that at dosage of 3,000 μg/ml, the apoptosis of T47D was about 50%. Therefore, this Thai herbal recipe showed the promising antiproliferative activity on human breast cancer cell line, T47D, with the mechanism of inducing apoptosis in this cell line.

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