[ Mahidol University. Journal of Pharmaceutical Sciences - ONLINE ]
[ By Faculty of Pharmacy, Mahidol University. THAILAND]
Mahidol University Journal of Pharmaceutical Sciences
Abstracted/Indexed in SciFinder since 1974 (former name  "Warasan Phesatchasat")
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The Mahidol University Journal of Pharmaceutical Sciences is committed to the timely publication of innovative papers and reviews. Manuscripts submitted for publication in this journal must not have been previously published and are not under consideration for publication in any other media. All manuscripts accepted for publication are peer-reviewed... read more


Study of Oxaliplatin-based Chemotherapy-Induced Neurotoxicity in Colorectal Cancer Thai Patients

J. Wutthikonsammakit, B. Chindavijak,* U. Chaikredkaew, W. Lausoontornsiri

Oxaliplatin is known to cause neurotoxicity, especially peripheral neuropathy. To prevent such symptom, oxaliplatin is recommended to be administered in a prolonged infusion time. This was an observational study to determine the incidence of neurotoxicity in colorectal cancer Thai patients of the National Cancer Institute who received different infusion time of oxaliplatin. All patients were prospectively determined for neurotoxicity at each cycle of chemotherapy in which oxaliplatin was infused for 2-, 4-, and 6-hour per doctor’s order. The severity of symptoms was graded according to the Oxaliplatin-Specific Neurotoxicity Scale. At the last cycle, patients answered the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire to evaluate quality of life. Thirty two patients were enrolled and 75% were infused for 2-hour regimen. Motor neurotoxicity and sensory alteration were presented in almost all cycles. Incidence of increasing severity was found along the increasing cycle, and it was similar among the three groups of different infusion time. The median cumulative dose of oxaliplatin in the group without symptoms, grade 1, 2 and 3 neurotoxicity were 300, 468.8, 671.9, and 1,031.3 mg/m2, respectively (ranged from 112.5 to 937.5 mg/m2, 162.5 to 1,012.5 mg/m2, 150 to 975 mg/m2, and 812.5 to 1,125 mg/m2, respectively). Total scores of quality of life were good, higher than 70. It was concluded that oxaliplatin caused progressive neurotoxicity along the increasing cycle and there was a tendency that prolonged duration of infusion resulted in lower incidence of neurotoxicity.

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Our graduate programmes have established international academic cooperation with the renowned universities in the United States of America, United Kingdom, Germany, France, Japan and Australia. All graduate programmes offer career routes into public sectors, industry and academia and are suitable for both pharmacists and scientists who are interested to do a research in pharmacy and pharmaceutical sciences.

At present, Faculty of Pharmacy, Mahidol University offers four Master’s degree programmes and five Doctoral degree programmes

MUPY staff attended the 3rd Meeting of South East Asian Pharmacogenomics Research Network (SEAPharm) Symposium
MUPY staff officially visited Faculty of Pharmacy, Universitas Indonesia, Indonesia
MUPY staff officially visited Faculty of Pharmacy, Universitas Pancasila, Indonesia
MUPY exchange students participated the internship program at Faculty of Pharmacy, Universitas Surabaya, Indonesia
The exit presentation and evaluation of exchange students from College of Pharmacy, University of Kentucky, USA

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