[ Mahidol University. Journal of Pharmaceutical Sciences - ONLINE ]
[ By Faculty of Pharmacy, Mahidol University. THAILAND]
Mahidol University Journal of Pharmaceutical Sciences
Abstracted/Indexed in SciFinder since 1974 (former name  "Warasan Phesatchasat")
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The Mahidol University Journal of Pharmaceutical Sciences is committed to the timely publication of innovative papers and reviews. Manuscripts submitted for publication in this journal must not have been previously published and are not under consideration for publication in any other media. All manuscripts accepted for publication are peer-reviewed... read more


Pandanus amaryllifolius Root Extract Prolongs Sleeping Time and Reduces Locomotor Activity in Mice

P. Peungvicha*, Y. Wongkrajang, B. Kongsaktrakoon , R. Temsiririrkul and H. Watanabe

The investigation on locomotor activity and hypnotic effect of the decoction of Pandanus amaryllifolius root was performed in mice. The extract at doses of 1- 2 g/kg significantly decreased the spontaneous locomotor activity in a dose-dependent manner during 30 minutes after feeding. The extract at the dose of 4 g/kg significantly suppressed the locomotor activity in amphetamine-treated mice but the lower dose cannot. In addition, the extract at doses of 0.5-2 g/kg feeding prolonged the pentobarbital-induced sleeping time in both sexes of mice. This effect was not attenuated by flumazenil (a selective benzodiazepine receptor antagonist).These results suggest that the water extract of Pandanus amaryllifolius root suppressed the spontaneous and amphetamine-activated locomotor activity. The extract also potentiated the effect of pentobarbital sodium on sleep which is not implicated with benzodiazepine receptor system.

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MUPY cordially welcomed Mr. Eko Setiawan, M.Sc., Apt. from University of Surabaya, Indonesia as a visiting scholar
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