[ Mahidol University. Journal of Pharmaceutical Sciences - ONLINE ]
[ By Faculty of Pharmacy, Mahidol University. THAILAND]
Mahidol University Journal of Pharmaceutical Sciences
Abstracted/Indexed in SciFinder since 1974 (former name  "Warasan Phesatchasat")
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The Mahidol University Journal of Pharmaceutical Sciences is committed to the timely publication of innovative papers and reviews. Manuscripts submitted for publication in this journal must not have been previously published and are not under consideration for publication in any other media. All manuscripts accepted for publication are peer-reviewed... read more


Therapeutic Potential of SGLT2 Inhibitors in Treating Type 2 Diabetes Mellitus

M. Amin and N. Suksomboon*

Current therapies in type 2 diabetes management lose their efficacy because of their dependence on ?-cell function which decreases with the passage of time. In kidneys, filtered glucose is reabsorbed mostly by the sodium glucose cotransporter-2 (SGLT-2) proteins which are located in the S1 segment of proximal convoluted tubules. SGLT2 inhibitors reduce this reabsorption process by blocking SGLT2 proteins and reduce glycemic levels by promoting urinary glucose excretion which is an insulin independent phenomenon. This loss of glucose in urine is also associated with decrease in body weight by creating an energy deficit and to some extent reduction in blood pressure due to an osmotic diuretic effect. This review focuses on therapeutic potential of SGLT2 inhibitors with a view to identify their role in diabetes management. The available evidence suggests that SGLT2 inhibitors are safe, efficacious and well tolerated across a large group of patients. Provided that the long term safety of this class is established, it is very likely that these agents shall assume a major role in diabetes management.

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Our graduate programmes have established international academic cooperation with the renowned universities in the United States of America, United Kingdom, Germany, France, Japan and Australia. All graduate programmes offer career routes into public sectors, industry and academia and are suitable for both pharmacists and scientists who are interested to do a research in pharmacy and pharmaceutical sciences.

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MUPY exchange students participated the internship program at Faculty of Pharmacy, University of Santo Tomas, Philippines
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